Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats
N. Keyshams, S. R. Fatemi Tabatabaei , H. Najafzadehvarzi , A. Ashrafi
Zahedan Journal of Research in Medical Sciences, 15 (2013) 59 - 64
Background: Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects of ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.
Materials and Methods: In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15
mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDLc and LDL-c were measured at both time and compared between groups.
Results: All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p<0.05). All treatment decreased TG, TC and LDL-c significantly (p<0.001).
Conclusion: Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.